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Env gp120 clade C IgG responses after each boost were detected in 25% and 100% of participants. Env IgG breadth responses across clades A, B, C and AE, BC recombinant forms were elicited in up to 86% of participants. Tier 1 nAb responses (clade C) were elicited in 70% of participants at a low magnitude (11.2 to 41.8 ID 50) 2 weeks after last boost.